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  1. #1
    Weed Watcher
    Join Date
    Jun 2012
    Dublinskunkfiend is offline
    12822 times
    As a sufferer of Sleep Apnea,
    It has messed up my life in a big way, it started with not been able to sleep.
    To depression,anxiety, and panic attacks. A good few years back.
    I started to search for something other than pharma meds, to help me sleep.
    As I was not allowed sleeping meds, as they worsened the condition.
    After loads of self medicating with lots of different drugs including Ketamine / Ket.
    And loads of Madness, I found an article that has helped things immensely.

    Below is an abstract.

    Study Objectives:

    Serotonin, acting in the peripheral nervous system, can exacerbate sleep-related apnea, and systemically administered serotonin antagonists reduce sleep-disordered respiration in rats and bulldogs. Because cannabinoid receptor agonists are known to inhibit the excitatory effects of serotonin on nodose ganglion cells, we examined the effects of endogenous (oleamide) and exogenous ('9 -tetrahydrocannabinol; 9 THC)
    cannabimimetic agents on sleep-related apnea.
    Design: Sleep architecture, respiratory pattern, and apnea expression in rats were assessed by polysomnography. A repeated measures, within- subjects, fully nested crossover design was used in which each animal was recorded on exactly 12 occasions.

    Participants: Eleven adult male Sprague-Dawley rats were instrumented for chronic polysomnography.

    Interventions Animals were recorded following intraperitoneal injection of various doses of '9THC, oleamide, and serotonin, alone and in combination.

    Measurements and Results: Our data show that '9THC and oleamide each stabilized respiration during all sleep stages. With'9THC, apnea index decreased by 42% (F=2.63; p=0.04) and 58% (F=2.68; p=0.04) in NREM and REM sleep, respectively. Oleamide produced equivalent apnea suppression. This observation suggests an important role for endocannabinoids in maintaining autonomic stability during sleep. Oleamide and '9THC blocked serotonin-induced exacerbation of sleep apnea (p<0.05 for each), suggesting that inhibitory coupling between cannabinoids and serotonin receptors in the peripheral nervous system may act on apnea expression.

    Conclusions: This study demonstrates potent suppression of sleep-related apnea by both exogenous and endogenous cannabinoids. These findings are of relevance to the pathogenesis and pharmacological treatment of sleep-related breathing disorders.

    Here is the full study,
    to which I hope it helps other sufferers of this condition.


    Last edited by Dublinskunkfiend; 08-27-2012 at 08:55 PM.

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